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Issue 7, 2014
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Zinc'ing sensibly: controlling zinc homeostasis at the transcriptional level

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Abstract

Zinc-responsive transcription factors are found in all kingdoms of life and include the transcriptional activators ZntR, SczA, Zap1, bZip19, bZip23, and MTF-1, and transcriptional repressors Zur, AdcR, Loz1, and SmtB. These factors have two defining features; their activity is regulated by zinc and they all play a central role in zinc homeostasis by controlling the expression of genes that directly affect zinc levels or its availability. This review summarizes what is known about the mechanisms by which each of these factors sense changes in intracellular zinc levels and how they control zinc homeostasis through target gene regulation. Other factors that influence zinc ion sensing are also discussed.

Graphical abstract: Zinc'ing sensibly: controlling zinc homeostasis at the transcriptional level

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Publication details

The article was received on 28 Feb 2014, accepted on 04 Apr 2014 and first published on 04 Apr 2014


Article type: Critical Review
DOI: 10.1039/C4MT00064A
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Citation: Metallomics, 2014,6, 1198-1215

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    Zinc'ing sensibly: controlling zinc homeostasis at the transcriptional level

    S. Choi and A. J. Bird, Metallomics, 2014, 6, 1198
    DOI: 10.1039/C4MT00064A

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