Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants†
Evaluation of Zn affinity for the amyloid-β peptide involved in Alzheimer's disease and its modified counterparts is reported. This was made possible by the use of a new water-soluble chelator, the properties of which have also been described. Changes in the peptide sequence that impact Zn affinity are briefly discussed.
- This article is part of the themed collection: Zinc in the Biosciences