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Issue 3, 2015
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Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

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Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

Graphical abstract: Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

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Publication details

The article was received on 13 Sep 2014, accepted on 07 Oct 2014 and first published on 08 Oct 2014


Article type: Concise Article
DOI: 10.1039/C4MD00406J
Med. Chem. Commun., 2015,6, 403-406

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    Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

    A. Manos-Turvey, E. E. Watson, M. L. Sykes, A. J. Jones, J. B. Baell, M. Kaiser, V. M. Avery and R. J. Payne, Med. Chem. Commun., 2015, 6, 403
    DOI: 10.1039/C4MD00406J

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