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Issue 3, 2015
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Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

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Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

Graphical abstract: Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

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Article information


Submitted
13 Sep 2014
Accepted
07 Oct 2014
First published
08 Oct 2014

Med. Chem. Commun., 2015,6, 403-406
Article type
Concise Article

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

A. Manos-Turvey, E. E. Watson, M. L. Sykes, A. J. Jones, J. B. Baell, M. Kaiser, V. M. Avery and R. J. Payne, Med. Chem. Commun., 2015, 6, 403
DOI: 10.1039/C4MD00406J

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