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Issue 7, 2014
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The biology and synthesis of α-hydroxytropolones

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Abstract

α-Hydroxytropolones are a subclass of the troponoid family of natural products that are of high interest due to their broad biological activity and potential as treatment options for several diseases. Despite this promise, there have been scarce synthetic chemistry-driven optimization studies on the molecules. The following review highlights key developments in the biological studies conducted on α-hydroxytropolones to date, including the few synthetic chemistry-driven optimization studies. In addition, we provide an overview of the methods currently available to access these molecules. This review is intended to serve as a resource for those interested in biological activity of α-hydroxytropolones, and inspire the development of new synthetic methods and strategies that could aid in this pursuit.

Graphical abstract: The biology and synthesis of α-hydroxytropolones

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Article information


Submitted
13 Feb 2014
Accepted
26 Mar 2014
First published
27 Mar 2014

Med. Chem. Commun., 2014,5, 842-852
Article type
Review Article
Author version available

The biology and synthesis of α-hydroxytropolones

C. Meck, M. P. D'Erasmo, D. R. Hirsch and R. P. Murelli, Med. Chem. Commun., 2014, 5, 842
DOI: 10.1039/C4MD00055B

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