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Issue 3, 2014
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Target validation using in-cell small molecule clickable imaging probes

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Abstract

The application of in-cell click chemistry to the visualization of chemical probes in chemical biology experiments is reviewed. Fluorometric dyes can perturb the distribution, and function, of a labelled chemical tool – probes incorporating ‘silent’ clickable handles can therefore report on more relevant subcellular distribution and biomolecular interaction events. The influence this research has had on target validation and molecular mode of action studies is also highlighted.

Graphical abstract: Target validation using in-cell small molecule clickable imaging probes

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Publication details

The article was received on 26 Sep 2013, accepted on 18 Nov 2013 and first published on 22 Nov 2013


Article type: Review Article
DOI: 10.1039/C3MD00277B
Med. Chem. Commun., 2014,5, 247-254

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    Target validation using in-cell small molecule clickable imaging probes

    B. Ghosh and L. H. Jones, Med. Chem. Commun., 2014, 5, 247
    DOI: 10.1039/C3MD00277B

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