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Issue 3, 2014
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Target validation using in-cell small molecule clickable imaging probes

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Abstract

The application of in-cell click chemistry to the visualization of chemical probes in chemical biology experiments is reviewed. Fluorometric dyes can perturb the distribution, and function, of a labelled chemical tool – probes incorporating ‘silent’ clickable handles can therefore report on more relevant subcellular distribution and biomolecular interaction events. The influence this research has had on target validation and molecular mode of action studies is also highlighted.

Graphical abstract: Target validation using in-cell small molecule clickable imaging probes

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Article information


Submitted
26 Sep 2013
Accepted
18 Nov 2013
First published
22 Nov 2013

Med. Chem. Commun., 2014,5, 247-254
Article type
Review Article

Target validation using in-cell small molecule clickable imaging probes

B. Ghosh and L. H. Jones, Med. Chem. Commun., 2014, 5, 247
DOI: 10.1039/C3MD00277B

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