Oligomeric state affects oxygen dissociation and diguanylate cyclase activity of globin coupled sensors

Abstract

Bacterial biofilm formation is regulated by enzymes, such as diguanylate cyclases, that respond to environmental signals and alter c-di-GMP levels. Diguanylate cyclase activity of two globin coupled sensors is shown to be regulated by gaseous ligands, with cyclase activity and O₂ dissociation affected by protein oligomeric state.