Issue 17, 2014

Gradient generation platforms: new directions for an established microfluidic technology

Abstract

Microscale platforms are enabling for cell-based studies as they allow the recapitulation of physiological conditions such as extracellular matrix (ECM) configurations and soluble factors interactions. Gradient generation platforms have been one of the few applications of microfluidics that have begun to be translated to biological laboratories and may become a new “gold standard”. Though gradient generation platforms are now established, their full potential has not yet been realized. Here, we will provide our perspective on milestones achieved in the development of gradient generation and cell migration platforms, as well as emerging directions such as using cell migration as a diagnostic readout and attaining mechanistic information from cell migration models.

Graphical abstract: Gradient generation platforms: new directions for an established microfluidic technology

Article information

Article type
Frontier
Submitted
15 Apr 2014
Accepted
25 Jun 2014
First published
26 Jun 2014

Lab Chip, 2014,14, 3241-3247

Author version available

Gradient generation platforms: new directions for an established microfluidic technology

E. Berthier and D. J. Beebe, Lab Chip, 2014, 14, 3241 DOI: 10.1039/C4LC00448E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements