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Issue 13, 2014
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Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

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Abstract

Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loading capacity and efficiency is described. We performed experimental and computational studies in order to evaluate the trapping efficiencies, maximum loading capacity and magnetic alignment of the nanoparticles. The results showed that capacity and trapping efficiencies are directly related to the flow rate, elution time and reactor type. Based on our results and the developed magnetic microreactor, we describe a model multistep surface derivatization procedure of SPIONs.

Graphical abstract: Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

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Publication details

The article was received on 21 Feb 2014, accepted on 08 Apr 2014 and first published on 08 Apr 2014


Article type: Paper
DOI: 10.1039/C4LC00229F
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Citation: Lab Chip, 2014,14, 2276-2286
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    Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

    R. G. Digigow, J.-F. Dechézelles, J. Kaufmann, D. Vanhecke, H. Knapp, M. Lattuada, B. Rothen-Rutishauser and A. Petri-Fink, Lab Chip, 2014, 14, 2276
    DOI: 10.1039/C4LC00229F

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