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Issue 13, 2014
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Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

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Abstract

Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loading capacity and efficiency is described. We performed experimental and computational studies in order to evaluate the trapping efficiencies, maximum loading capacity and magnetic alignment of the nanoparticles. The results showed that capacity and trapping efficiencies are directly related to the flow rate, elution time and reactor type. Based on our results and the developed magnetic microreactor, we describe a model multistep surface derivatization procedure of SPIONs.

Graphical abstract: Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

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Article information


Submitted
21 Feb 2014
Accepted
08 Apr 2014
First published
08 Apr 2014

Lab Chip, 2014,14, 2276-2286
Article type
Paper
Author version available

Magnetic microreactors for efficient and reliable magnetic nanoparticle surface functionalization

R. G. Digigow, J.-F. Dechézelles, J. Kaufmann, D. Vanhecke, H. Knapp, M. Lattuada, B. Rothen-Rutishauser and A. Petri-Fink, Lab Chip, 2014, 14, 2276
DOI: 10.1039/C4LC00229F

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