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Issue 11, 2014
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Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species

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Abstract

Advanced Glycation Endproducts (AGEs) are a heterogeneous group of molecules produced from non-enzymatic glycation. Accumulation of AGEs in vivo plays an important role in the pathology of chronic human diseases including type-2 diabetes and Alzheimer's disease. Natural AGEs inhibitors such as the pomegranate (Punica granatum) fruit show great potential for the management of these diseases. Herein, we investigated the in vitro anti-glycation effects of a pomegranate fruit extract (PE), its phenolic constituents [punicalagin (PA), ellagic acid (EA) and gallic acid (GA)], and their in vivo derived colonic metabolites [urolithin A (UA) and urolithin B (UB)]. All of the samples showed anti-glycation activities and PE, PA, and EA were more potent inhibitors than the positive control, aminoguanidine. PE and the purified phenolics also exhibited carbonyl scavenger reactivity. Our study suggests that pomegranate may offer an attractive dietary strategy for the prevention and treatment of AGE-related diseases such as type-2 diabetes and Alzheimer's disease.

Graphical abstract: Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species

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Supplementary files

Article information


Submitted
18 Jun 2014
Accepted
10 Sep 2014
First published
11 Sep 2014

Food Funct., 2014,5, 2996-3004
Article type
Paper
Author version available

Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species

W. Liu, H. Ma, L. Frost, T. Yuan, J. A. Dain and N. P. Seeram, Food Funct., 2014, 5, 2996
DOI: 10.1039/C4FO00538D

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