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Issue 4, 2014
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Probiotic actions on diseases: implications for therapeutic treatments

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The ecology of gut microflora, which colonizes all body surfaces, has long coevolved with its hosts in a complicated fashion. Health benefits conferred by gut microflora include defense against invading pathogens, improvement of nutritional bioavailability, and development of the regional and systemic immune systems. The past decade has witnessed growing interest in the fact that the gut microflora affects the host's energy homeostasis by means of various mechanisms, including supplying nourishment from indigestible compounds, producing small biomolecules responsible for lipid profiles, and participating in the absorption, distribution, metabolism and excretion of nutrition. Much in vitro and in vivo research has indicated that aberrant gut microflora plays an important role in the pathogenesis of a wide spectrum of diseases. This is accomplished by a shift in focus, from laying an emphasis on pharmacotherapy to placing more effort on gut microflora normalization. The objectives of this review include illustrating trends in the clinical application of probiotics on diseases, as well as discussing current methodology limitations on probiotic selection. Furthermore, it is expected to shed light on the nature of probiotics, with the aim of giving greater insight into the implications for clinical use of probiotics in the treatment of diseases.

Graphical abstract: Probiotic actions on diseases: implications for therapeutic treatments

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The article was received on 17 Nov 2013, accepted on 24 Dec 2013 and first published on 08 Jan 2014

Article type: Review Article
DOI: 10.1039/C3FO60600G
Food Funct., 2014,5, 625-634

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    Probiotic actions on diseases: implications for therapeutic treatments

    Y. Chiu, S. Lin, J. Tsai and M. Lin, Food Funct., 2014, 5, 625
    DOI: 10.1039/C3FO60600G

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