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Volume 205, 2017
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Real-time dynamic SERS detection of galectin using glycan-decorated gold nanoparticles

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Abstract

We present the application of surface-enhanced Raman scattering (SERS) spectroscopy for the fast, sensitive and highly specific detection of the galectin-9 (Gal-9) protein in binding buffer (mimicking natural conditions). The method involves the use of specifically designed nanotags comprising glycan-decorated gold nanoparticles encoded with 4-mercaptobenzoic acid. At fast time scales Gal-9 can be detected down to a concentration of 1.2 nM by monitoring the SERS signal of the reporter, driven by aggregation of the functionalized Au NPs tags, induced by Gal-9 recognition. We additionally demonstrate that the sensitivity and concentration working range of the sensor can be tuned via control of aggregation dynamics and cluster size distribution.

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Submitted
07 Apr 2017
Accepted
04 May 2017
First published
04 May 2017

Faraday Discuss., 2017,205, 363-375
Article type
Paper

Real-time dynamic SERS detection of galectin using glycan-decorated gold nanoparticles

J. Langer, I. García and L. M. Liz-Marzán, Faraday Discuss., 2017, 205, 363
DOI: 10.1039/C7FD00123A

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