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Volume 169, 2014
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3D molecular models of whole HIV-1 virions generated with cellPACK

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Abstract

As knowledge of individual biological processes grows, it becomes increasingly useful to frame new findings within their larger biological contexts in order to generate new systems-scale hypotheses. This report highlights two major iterations of a whole virus model of HIV-1, generated with the cellPACK software. cellPACK integrates structural and systems biology data with packing algorithms to assemble comprehensive 3D models of cell-scale structures in molecular detail. This report describes the biological data, modeling parameters and cellPACK methods used to specify and construct editable models for HIV-1. Anticipating that cellPACK interfaces under development will enable researchers from diverse backgrounds to critique and improve the biological models, we discuss how cellPACK can be used as a framework to unify different types of data across all scales of biology.

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Article information


Submitted
19 Feb 2014
Accepted
19 Mar 2014
First published
25 Sep 2014

This article is Open Access

Faraday Discuss., 2014,169, 23-44
Article type
Paper

3D molecular models of whole HIV-1 virions generated with cellPACK

G. T. Johnson, D. S. Goodsell, L. Autin, S. Forli, M. F. Sanner and A. J. Olson, Faraday Discuss., 2014, 169, 23
DOI: 10.1039/C4FD00017J

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