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Issue 3, 2016
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Non-invasive evaluation of cardiac repolarization in mice exposed to single-wall carbon nanotubes and ceria nanoparticles via intratracheal instillation

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Abstract

We present results obtained from electrocardiogram (ECG) measurements performed on mice exposed to single-walled carbon nanotubes and ceria nanoparticles through instillation. From these non-invasive ECG measurements, QT and RR intervals were obtained at various times after exposure and used to compute a novel metric for evaluating cardiac signal propagation stability, the reserve of refractoriness (RoR). It is demonstrated that while the isolated QT and RR intervals are essentially uncorrelated with histological data from hematoxylin and eosin stains of control and exposed tissue samples, the RoR is sensitive to cardiovascular effects from the exposure to nanoparticles.

Graphical abstract: Non-invasive evaluation of cardiac repolarization in mice exposed to single-wall carbon nanotubes and ceria nanoparticles via intratracheal instillation

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Supplementary files

Article information


Submitted
19 Oct 2015
Accepted
29 Mar 2016
First published
30 Mar 2016

Environ. Sci.: Nano, 2016,3, 611-618
Article type
Paper
Author version available

Non-invasive evaluation of cardiac repolarization in mice exposed to single-wall carbon nanotubes and ceria nanoparticles via intratracheal instillation

K. Kosaraju, J. L. Lancaster, S. R. Meier, S. Crawford, S. Hurley, S. Aravamudhan and J. M. Starobin, Environ. Sci.: Nano, 2016, 3, 611
DOI: 10.1039/C5EN00225G

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