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Issue 3, 2017
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Hexamethylenetetramine carboxyborane: synthesis, structural characterization and CO releasing properties

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Abstract

Carbon monoxide, although widely known as a toxic gas, has received great attention in the past few decades due to its promising role as a medical gas. Several classes of carbon monoxide releasing molecules (CORMs) have been synthesised with many of them having pharmacological activities under physiological conditions. Herein, we report the synthesis and structural characterization of the first example of amine carboxyborane that releases CO under physiological conditions without the aid of inducers. A representative compound hexamethylenetetramine carboxyborane (HMTA-CB) described here has a half-life of 2.7 days and gradually releases CO with the rate constant of 3.0 × 10−6 s−1. Its ability to promote cell growth shows the beneficial effect of slow CO release to supplement CO in small amounts over time.

Graphical abstract: Hexamethylenetetramine carboxyborane: synthesis, structural characterization and CO releasing properties

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Publication details

The article was received on 05 Oct 2016, accepted on 10 Dec 2016 and first published on 12 Dec 2016


Article type: Paper
DOI: 10.1039/C6DT03856E
Dalton Trans., 2017,46, 882-889

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    Hexamethylenetetramine carboxyborane: synthesis, structural characterization and CO releasing properties

    T. I. Ayudhya, C. C. Raymond and N. N. Dingra, Dalton Trans., 2017, 46, 882
    DOI: 10.1039/C6DT03856E

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