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Issue 35, 2014
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Oxovanadium(iv) complexes of curcumin for cellular imaging and mitochondria targeted photocytotoxicity

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Abstract

Oxovanadium(IV) complexes [VO(R-tpy)(cur)](ClO4) (1, 2) of curcumin (Hcur) and terpyridine ligands (R-tpy) where R is phenyl (phtpy in 1) or p-triphenylphosphonium methylphenyl bromide (C6H4CH2PPh3Br) (TPP-phtpy in 2) were prepared and characterized and their DNA photocleavage activity, photocytotoxicity and cellular localization in cancer cells (HeLa and MCF-7) were studied. Acetylacetonate (acac) complexes [VO(R-tpy)(acac)](ClO4) of phtpy (3) and TPP-phtpy (4) were prepared and used as the control species. These complexes showed efficient cleavage of pUC19 DNA in visible light of 454 nm and near-IR light of 705 nm. Complexes 1 and 2 showed significant photocytotoxicity in visible light of 400–700 nm. FACS analysis showed sub-G1/G0 phase cell-cycle arrest in cancer cells when treated with 1 and 2 in visible light in comparison with the dark controls. Fluorescence microscopic studies revealed specific localization of the p-triphenylphosphonium complex 2 in the mitochondria of MCF-7 cancer cells whereas no such specificity was observed for complex 1.

Graphical abstract: Oxovanadium(iv) complexes of curcumin for cellular imaging and mitochondria targeted photocytotoxicity

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Supplementary files

Article information


Submitted
21 May 2014
Accepted
11 Jul 2014
First published
15 Jul 2014

Dalton Trans., 2014,43, 13358-13369
Article type
Paper

Oxovanadium(IV) complexes of curcumin for cellular imaging and mitochondria targeted photocytotoxicity

B. Banik, K. Somyajit, G. Nagaraju and A. R. Chakravarty, Dalton Trans., 2014, 43, 13358
DOI: 10.1039/C4DT01487A

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