A new fluorescent probe for Al3+ based on rhodamine 6G and its application to bioimaging

Abstract

A water-soluble rhodamine-based derivative (L) has been rationally designed for selective recognition of Al³⁺ in aqueous medium with good sensitivity. The addition of Al³⁺ to the aqueous solution of L induces a remarkable fluorescence enhancement along with obvious color change detected by the naked eye, due to the ring-opening mechanism of the rhodamine spirolactam, which has been proved by single crystal diffraction analyses directly. The recognizing behavior has been investigated both experimentally and computationally. Furthermore, the fluorescent probe can also be used as a bioimaging reagent for detection of Al³⁺ in living cells.