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Issue 23, 2014
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Metal-catalyzed activation of ethers via C–O bond cleavage: a new strategy for molecular diversity

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Abstract

In 1979, the seminal work of Wenkert set the standards for the utilization of aryl and vinyl ethers as coupling partners via C–O bond-cleavage. Although the topic remained dormant for almost three decades, the last few years have witnessed a renaissance in this area of expertise, experiencing an exponential growth and becoming a significant discipline within the cross-coupling arena. The means to utilize readily accessible aryl or vinyl ethers as counterparts does not only represent a practical, powerful and straightforward alternative to organic halides, but also constitutes an excellent opportunity to improve our chemical knowledge about a relatively unexplored area of expertise. This review summarizes the most significant developments in the area of C–O bond-cleavage when employing aryl or vinyl ethers, providing a detailed overview of the current state of the art and including future aspects, when applicable.

Graphical abstract: Metal-catalyzed activation of ethers via C–O bond cleavage: a new strategy for molecular diversity

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Article information


Submitted
17 Jun 2014
First published
26 Aug 2014

Chem. Soc. Rev., 2014,43, 8081-8097
Article type
Review Article
Author version available

Metal-catalyzed activation of ethers via C–O bond cleavage: a new strategy for molecular diversity

J. Cornella, C. Zarate and R. Martin, Chem. Soc. Rev., 2014, 43, 8081
DOI: 10.1039/C4CS00206G

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