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Issue 20, 2014
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“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

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Abstract

Peptides that comprise the functional subunits of proteins have been conjugated to versatile materials (biomolecules, polymers, surfaces and nanoparticles) in an effort to modulate cell responses, specific binding affinity and/or self-assembly behavior. However, the efficient and convenient synthesis of peptide-conjugates, especially the constructs with multiple types of peptide functionality remains challenging. In this critical review, we focus on “click” reactions that have been used to synthesis peptide-functionalized conjugates, introducing their reaction conditions, specifically elucidating parameters that influence reaction kinetics and total conversion, and highlighting examples that have been completed recently. Moreover, orthogonal “click” reactions that synthesize multi-functional biomaterials in a one-pot or sequential manner are noted. Through this review, a comprehensive understanding of “click” reactions aims to provide insight on how one might choose suitable “click” reactions to constitute peptide-functionalized molecules/surfaces/matrices for the development of advanced biomaterials.

Graphical abstract: “Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

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Article information


Submitted
28 Apr 2014
First published
04 Jul 2014

Chem. Soc. Rev., 2014,43, 7013-7039
Article type
Review Article
Author version available

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

W. Tang and M. L. Becker, Chem. Soc. Rev., 2014, 43, 7013
DOI: 10.1039/C4CS00139G

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