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Issue 18, 2014
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Addition of CF3 across unsaturated moieties: a powerful functionalization tool

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Abstract

In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF3 groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF3 and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential.

Graphical abstract: Addition of CF3 across unsaturated moieties: a powerful functionalization tool

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Article information


Submitted
15 Jan 2014
First published
02 May 2014

This article is Open Access

Chem. Soc. Rev., 2014,43, 6598-6608
Article type
Review Article

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

E. Merino and C. Nevado, Chem. Soc. Rev., 2014, 43, 6598
DOI: 10.1039/C4CS00025K

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