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Issue 15, 2014
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Gold-catalyzed C(sp3)–H bond functionalization

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Abstract

C–H bonds are ubiquitous in organic molecules. Homogenous gold-catalyzed direct functionalization of unsaturated C–H bonds has emerged as a powerful method in our synthetic toolbox. However, Csp3–H bonds have larger dissociation energy and lower proton acidity, and thus the efficient and exquisitely selective cleavage of this kind of chemical bonds for the formation of new carbon–carbon and carbon–heteroatom bonds is still a great challenge. In this tutorial review, we will highlight the recent achievements of gold-catalyzed oxidative and redox–neutral Csp3–H bond functionalization, which opens new avenues for economical and sustainable construction of fine chemicals.

Graphical abstract: Gold-catalyzed C(sp3)–H bond functionalization

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Article information


Submitted
02 Jan 2014
First published
23 May 2014

Chem. Soc. Rev., 2014,43, 5245-5256
Article type
Tutorial Review
Author version available

Gold-catalyzed C(sp3)–H bond functionalization

J. Xie, C. Pan, A. Abdukader and C. Zhu, Chem. Soc. Rev., 2014, 43, 5245
DOI: 10.1039/C4CS00004H

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