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Issue 14, 2014
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How cyclobutanes are assembled in nature – insights from quantum chemistry

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Abstract

Biosynthetic production of cyclobutanes leads to many complex natural products. Recently, theoretical work employing quantum chemical calculations has shed light on many of the details of cyclobutane-formation, in particular, for terpene natural products. Specific insights and general principles derived from these theoretical studies are described herein.

Graphical abstract: How cyclobutanes are assembled in nature – insights from quantum chemistry

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Article information


Submitted
09 Dec 2013
First published
07 Apr 2014

Chem. Soc. Rev., 2014,43, 5042-5050
Article type
Review Article

How cyclobutanes are assembled in nature – insights from quantum chemistry

Y. J. Hong and D. J. Tantillo, Chem. Soc. Rev., 2014, 43, 5042
DOI: 10.1039/C3CS60452G

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