Disulfide exchange: exposing supramolecular reactivity through dynamic covalent chemistry

Abstract

A Tutorial Review of the subtle supramolecular interactions influencing the outcomes of equilibrating systems, focusing on the dynamic covalent chemistry (DCC) of disulfide exchange reactions, is presented. We discuss the topics of cation–π interactions (2.1), hydrophobic effects (2.2), hydrogen bonding interactions (2.3) aromatic donor–acceptor interactions (2.4), and metal–ligand interactions (2.5) in the context of dynamic disulfide chemistry.