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Issue 42, 2014
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Characterization of C60 fullerene complexation with antibiotic doxorubicin

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Abstract

The aim of this paper was to provide the physico-chemical characterization of a key process leading to amplification of the antitumor effect of antibiotic Doxorubicin (Dox) in vivo and in vitro and occurring at the molecular level through complexation with C60 fullerene. A wide range of physico-chemical tools was used such as UV/Vis and NMR spectroscopies, atomic force microscopy, isothermal titration calorimetry and zeta-potential methods. The unusual thermodynamic behavior of the complexation process was reported, featuring unexpected and, to a certain extent, contradictory experimental observations. The explanation of the obtained results was proposed resulting in creation of a general view on aromatic drug binding with C60 fullerene. Based on these results some important practical outcomes for anticancer therapy were formulated.

Graphical abstract: Characterization of C60 fullerene complexation with antibiotic doxorubicin

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Publication details

The article was received on 29 Jul 2014, accepted on 01 Sep 2014 and first published on 03 Sep 2014


Article type: Paper
DOI: 10.1039/C4CP03367A
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Citation: Phys. Chem. Chem. Phys., 2014,16, 23164-23172

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    Characterization of C60 fullerene complexation with antibiotic doxorubicin

    Yu. I. Prylutskyy, M. P. Evstigneev, I. S. Pashkova, D. Wyrzykowski, A. Woziwodzka, G. Gołuński, J. Piosik, V. V. Cherepanov and U. Ritter, Phys. Chem. Chem. Phys., 2014, 16, 23164
    DOI: 10.1039/C4CP03367A

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