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Issue 37, 2014
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Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field

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Abstract

The dependence of longitudinal (r1) and transverse (r2) water proton relaxivities of ultrasmall gadolinium oxide (Gd2O3) nanoparticles on the surface coating ligand-size was investigated. Both r1 and r2 values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of D-glucuronic acid-coated ultrasmall Gd2O3 nanoparticles as T1 magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the in vitro cytotoxicity and using in vivo T1 MR images in a mouse in a 1.5 T MR field.

Graphical abstract: Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field

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Article information


Submitted
05 May 2014
Accepted
28 Jul 2014
First published
01 Aug 2014

Phys. Chem. Chem. Phys., 2014,16, 19866-19873
Article type
Paper
Author version available

Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field

C. R. Kim, J. S. Baeck, Y. Chang, J. E. Bae, K. S. Chae and G. H. Lee, Phys. Chem. Chem. Phys., 2014, 16, 19866
DOI: 10.1039/C4CP01946F

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