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Issue 37, 2014
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Sandwich crystals of butyl paraben

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Abstract

Butyl paraben crystals having a porous layer in between two solid non-porous layers have been produced by cooling crystallization in mixtures of ethanol and water. The outer layers are transparent and fully crystalline, while the middle layer appears to be polycrystalline and is full of pores of various dimensions, down to below 0.1 μm diameters. The thickness of the porous layer reaches about 40% of the whole crystal. The crystals contain one polymorph only and appear to be essentially fully crystalline. They are stable for more than a year when stored on the shelf at room temperature. When the crystals dissolve, the porous layer dissolves faster, leaving the outer layers for slower dissolution. The sandwich crystals are easily cleaved through the middle layer parallel to the (100) plane. This type of sandwich crystals may provide new useful properties to pharmaceutical solids, e.g. larger specific surface area, higher dissolution rates and improved compaction properties.

Graphical abstract: Sandwich crystals of butyl paraben

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Supplementary files

Article information


Submitted
29 Jun 2014
Accepted
30 Jul 2014
First published
30 Jul 2014

CrystEngComm, 2014,16, 8863-8873
Article type
Paper
Author version available

Sandwich crystals of butyl paraben

H. Yang, H. Chen and Å. C. Rasmuson, CrystEngComm, 2014, 16, 8863
DOI: 10.1039/C4CE01320D

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