Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 39, 2014
Previous Article Next Article

Formation of organic molecular nanocrystals under rigid confinement with analysis by solid state NMR

Author affiliations

Abstract

Crystallization in rigid confinement is a promising method to obtain organic molecular nanocrystals. However, the crystallization behavior and the related characterization methods are not well studied. Here we present a systematic study of the nucleation of organic molecular nanocrystals in rigid pores. Four different compounds were studied, ibuprofen, fenofibrate, griseofulvin and indomethacin, which range from simple to complex molecules. Solid-state Nuclear Magnetic Resonance (NMR) was employed to analyse the structure of these compounds inside pores which are difficult to characterize by other analytical methods. We successfully demonstrated the production of nano-crystalline ibuprofen, fenofibrate and griseofulvin in porous silica particles with ~40 nm pores. These nanocrystals showed significant enhancement in dissolution rates. These results help advance the fundamental understanding of nucleation under rigid confinement and may lead to potential applications in developing new formulations in the pharmaceutical industry.

Graphical abstract: Formation of organic molecular nanocrystals under rigid confinement with analysis by solid state NMR

Back to tab navigation

Supplementary files

Article information


Submitted
27 May 2014
Accepted
25 Aug 2014
First published
26 Aug 2014

CrystEngComm, 2014,16, 9345-9352
Article type
Paper
Author version available

Formation of organic molecular nanocrystals under rigid confinement with analysis by solid state NMR

X. Yang, T. C. Ong, V. K. Michaelis, S. Heng, J. Huang, R. G. Griffin and A. S. Myerson, CrystEngComm, 2014, 16, 9345
DOI: 10.1039/C4CE01087F

Social activity

Search articles by author

Spotlight

Advertisements