Issue 17, 2014

Polymorphism in cocrystals: a review and assessment of its significance

Abstract

Cocrystals have gained much interest in recent years owing to their potential to improve the physicochemical properties of the parent compounds. It was once thought that cocrystals could be a means to prevent polymorphism but many recent examples of cocrystal polymorphism have been discovered and reported. Similar to single component crystals, polymorphs of cocrystals can display significantly different properties. In this contribution, we present a survey of polymorphic cocrystals. The different types of polymorphs, namely synthon, conformational, packing, and tautomeric, are identified and discussed with representative examples. In addition, polymorphs of cocrystals that showed distinct physicochemical properties are highlighted.

Graphical abstract: Polymorphism in cocrystals: a review and assessment of its significance

Supplementary files

Article information

Article type
Highlight
Submitted
04 Oct 2013
Accepted
11 Feb 2014
First published
12 Feb 2014

CrystEngComm, 2014,16, 3451-3465

Polymorphism in cocrystals: a review and assessment of its significance

S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2014, 16, 3451 DOI: 10.1039/C3CE42008F

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