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Issue 9, 2015
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An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization

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Abstract

Transition metal free Brønsted acid mediated synthesis of biologically important pyrido[1,2-a]indole scaffolds through aza-Nazarov type cyclization of readily available diaryl(2-pyridyl)methanol using formic acid has been developed. This methodology has been successfully extended to synthesize atropisomers.

Graphical abstract: An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization

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Article information


Submitted
04 Nov 2014
Accepted
26 Nov 2014
First published
28 Nov 2014

Chem. Commun., 2015,51, 1701-1704
Article type
Communication

An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization

I. Karthikeyan, D. Arunprasath and G. Sekar, Chem. Commun., 2015, 51, 1701
DOI: 10.1039/C4CC08783F

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