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Issue 10, 2015
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Photo-induced sequence defined macromolecules via hetero bifunctional synthons

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We report the first photochemical protocol for the generation of sequence defined macromolecules employing two hetero bifunctional photoreactive synthons, exploiting the orthogonal nature of photochemical – via the use of caged dienes – and thermally driven ligation protocols. We demonstrate that the iterative alternating synthon addition to an initial bifunctional core under irradiation at ambient temperature enables the generation of a macromolecule with up to 10 units (M = 3231.58 g mol−1, Đ = 1.00). The resulting macromolecules are monodisperse and feature absolute chain end fidelity. The unit-by-unit construction of the macromolecule is evidenced by Nuclear Magnetic Resonance Spectroscopy, Electrospray Ionization Mass Spectrometry and Size Exclusion Chromatography. The fundamental principle demonstrated herein paves the way for employing photochemical strategies for the design of sequence defined polymers.

Graphical abstract: Photo-induced sequence defined macromolecules via hetero bifunctional synthons

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The article was received on 06 Nov 2014, accepted on 03 Dec 2014 and first published on 03 Dec 2014

Article type: Communication
DOI: 10.1039/C4CC08756A
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Citation: Chem. Commun., 2015,51, 1799-1802

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    Photo-induced sequence defined macromolecules via hetero bifunctional synthons

    N. Zydziak, F. Feist, B. Huber, J. O. Mueller and C. Barner-Kowollik, Chem. Commun., 2015, 51, 1799
    DOI: 10.1039/C4CC08756A

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