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Issue 2, 2015
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The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish

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Abstract

We report the development of a small fluorescent molecule, BDNCA3-D2, herein referred to as PT-Yellow. Soaking zebrafish embryos in PT-Yellow or intraperitoneal injection into adults results in non-toxic in vivo fluorescent labeling of the renal proximal tubules, the major site of blood filtrate reabsorption and a common target of injury in acute kidney injury. We demonstrate the applicability of this new compound as a rapid and simple readout for zebrafish kidney filtration and proximal tubule reabsorption function.

Graphical abstract: The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish

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Article information


Submitted
15 Oct 2014
Accepted
12 Nov 2014
First published
12 Nov 2014

Chem. Commun., 2015,51, 395-398
Article type
Communication
Author version available

The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish

V. Sander, S. Patke, S. Sahu, C. L. Teoh, Z. Peng, Y. Chang and A. J. Davidson, Chem. Commun., 2015, 51, 395
DOI: 10.1039/C4CC08075K

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