Issue 97, 2014

Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

Abstract

NHC-catalyzed divergent annulation of enals with heterocyclic enones was developed to produce benzofuran/indole-containing ε-lactones or spiro-heterocycles in a highly diastereo- and enantioselective fashion. The chemo-selectivity controlled by the chiral catalyst backbone is particularly noteworthy.

Graphical abstract: Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

Supplementary files

Article information

Article type
Communication
Submitted
02 Oct 2014
Accepted
16 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2014,50, 15309-15312

Author version available

Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

M. Wang, Z. Rong and Y. Zhao, Chem. Commun., 2014, 50, 15309 DOI: 10.1039/C4CC07788A

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