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Issue 96, 2014
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Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

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Abstract

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

Graphical abstract: Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

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Article information


Submitted
23 Sep 2014
Accepted
17 Oct 2014
First published
23 Oct 2014

Chem. Commun., 2014,50, 15202-15205
Article type
Communication

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

A. R. O. Cousins, D. Ritson, P. Sharma, M. F. G. Stevens, J. E. Moses and M. S. Searle, Chem. Commun., 2014, 50, 15202
DOI: 10.1039/C4CC07487D

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