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Issue 96, 2014
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Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

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Abstract

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

Graphical abstract: Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

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Publication details

The article was received on 23 Sep 2014, accepted on 17 Oct 2014 and first published on 23 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07487D
Chem. Commun., 2014,50, 15202-15205

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    Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

    A. R. O. Cousins, D. Ritson, P. Sharma, M. F. G. Stevens, J. E. Moses and M. S. Searle, Chem. Commun., 2014, 50, 15202
    DOI: 10.1039/C4CC07487D

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