Issue 96, 2014
From the journal:

Chemical Communications

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Alex R. O. Cousins,ab   Dougal Ritson,b   Pallavi Sharma,b   Malcolm F. G. Stevens,c   John E. Mosesb  and  Mark S. Searle*ab  

* Corresponding authors

a Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, UK
E-mail: mark.searle@nottingham.ac.uk

b School of Chemistry, University Park, University of Nottingham, Nottingham NG7 2RD, UK

c School of Pharmacy, University Park, University of Nottingham, Nottingham NG7 2RD, UK

Abstract

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

Graphical abstract: Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

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Article information

DOI
https://doi.org/10.1039/C4CC07487D
Article type
Communication
Submitted
23 Sep 2014
Accepted
17 Oct 2014
First published
23 Oct 2014

Chem. Commun., 2014,50, 15202-15205

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Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

A. R. O. Cousins, D. Ritson, P. Sharma, M. F. G. Stevens, J. E. Moses and M. S. Searle, Chem. Commun., 2014, 50, 15202 DOI: 10.1039/C4CC07487D

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