Attractive carbocyclic structures are accessed via a highly regio- and enantioselective aminocatalytic γ-addition of cyclic enals to vinyl phosphonates followed by a one-pot intramolecular Horner–Wadsworth–Emmons reaction. It is also demonstrated that nitro olefins can act as electrophiles in a similar reaction concept, providing carbocycles in equally high stereoselectivity.
B. S. Donslund, K. S. Halskov, L. A. Leth, B. M. Paz and K. A. Jørgensen, Chem. Commun., 2014, 50, 13676 DOI: 10.1039/C4CC06556E
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