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Issue 96, 2014
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Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide

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Abstract

A new cinchona alkaloid derived bifunctional tertiary amine-phosphoramide C1e is identified as a highly enantioselective catalyst for Michael addition of both unprotected 3-arylthio- and 3-alkylthiooxindoles to nitroolefins. The phosphoramide moiety of C1e plays an indispensable role in this reaction.

Graphical abstract: Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide

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Publication details

The article was received on 15 Aug 2014, accepted on 07 Oct 2014 and first published on 22 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC06417H
Chem. Commun., 2014,50, 15179-15182

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    Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide

    W. Gao, J. Yu, Y. Zhao, Y. Liu, F. Zhou, H. Wu and J. Zhou, Chem. Commun., 2014, 50, 15179
    DOI: 10.1039/C4CC06417H

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