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Issue 87, 2014
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MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

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Abstract

Novel methods were developed to isothermally detect target nucleic acids and initiate signal amplification cascades. The methods utilize target-specific MNAzymes to activate universal primer molecules. These primers can subsequently promote the autonomous synthesis of DNAzymes capable of cleaving nucleic acid substrates and generating signal, which further creates the potential for circular feedback.

Graphical abstract: MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

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Publication details

The article was received on 30 Jul 2014, accepted on 11 Sep 2014 and first published on 17 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC05919K
Citation: Chem. Commun., 2014,50, 13243-13246
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    MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

    S. M. Bone and A. V. Todd, Chem. Commun., 2014, 50, 13243
    DOI: 10.1039/C4CC05919K

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