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Issue 87, 2014
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MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

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Abstract

Novel methods were developed to isothermally detect target nucleic acids and initiate signal amplification cascades. The methods utilize target-specific MNAzymes to activate universal primer molecules. These primers can subsequently promote the autonomous synthesis of DNAzymes capable of cleaving nucleic acid substrates and generating signal, which further creates the potential for circular feedback.

Graphical abstract: MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

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Supplementary files

Article information


Submitted
30 Jul 2014
Accepted
11 Sep 2014
First published
17 Sep 2014

Chem. Commun., 2014,50, 13243-13246
Article type
Communication

MNAzymes provide a universal mechanism for triggering DNAzyme synthesis cascades

S. M. Bone and A. V. Todd, Chem. Commun., 2014, 50, 13243
DOI: 10.1039/C4CC05919K

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