Issue 98, 2014
From the journal:

Chemical Communications

Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)†

H.-J. Tong,‡a   C. Fitzgerald,a   P. J. Gallimore,a   M. Kalberer,a   M. K. Kuimova,b   P. C. Seville,c   A. D. Ward*d  and  F. D. Pope*e  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

b Department of Chemistry, Imperial College London, South Kensington Campus, London, UK

c School of Pharmacy, University of Birmingham, Edgbaston, Birmingham, UK

d Central Laser Facility, Rutherford Appleton Laboratory, Harwell, Oxford, UK
E-mail: andy.ward@stfc.ac.uk

e School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: f.pope@bham.ac.uk

Abstract

Individual micron-sized solid particles from a Salamol® pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environment that mimics the particle's travel from inhaler to lung.

Graphical abstract: Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

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Article information

DOI
https://doi.org/10.1039/C4CC05803H
Article type
Communication
Submitted
25 Jul 2014
Accepted
06 Oct 2014
First published
06 Oct 2014

Chem. Commun., 2014,50, 15499-15502

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Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

H.-J. Tong, C. Fitzgerald, P. J. Gallimore, M. Kalberer, M. K. Kuimova, P. C. Seville, A. D. Ward and F. D. Pope, Chem. Commun., 2014, 50, 15499 DOI: 10.1039/C4CC05803H

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