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Issue 81, 2014
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Synthesis of 1,2-amino alcohols via catalytic C–H amidation of sp3 methyl C–H bonds

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Abstract

Herein a new synthetic route to 1,2-amino alcohols is presented by using C–H amidation of sp3 methyl C–H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C–H amidation, and LAH reduction was then used to furnish β-amino alcohol products.

Graphical abstract: Synthesis of 1,2-amino alcohols via catalytic C–H amidation of sp3 methyl C–H bonds

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Supplementary files

Article information


Submitted
22 Jul 2014
Accepted
15 Aug 2014
First published
18 Aug 2014

Chem. Commun., 2014,50, 12073-12075
Article type
Communication
Author version available

Synthesis of 1,2-amino alcohols via catalytic C–H amidation of sp3 methyl C–H bonds

T. Kang, H. Kim, J. G. Kim and S. Chang, Chem. Commun., 2014, 50, 12073
DOI: 10.1039/C4CC05655H

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