Issue 89, 2014
From the journal:

Chemical Communications

A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging†

Xiao Ju Zou,a   Yi Cheng Ma,b   Lin E. Guo,a   Wen Xiang Liu,c   Mei Juan Liu,c   Cheng Gang Zou,b   Ying Zhou*a  and  Jun Feng Zhang*c  

* Corresponding authors

a College of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China
E-mail: yingzhou@ynu.edu.cn

b Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, PR China

c College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, PR China
E-mail: junfengzhang78@aliyun.com

Abstract

A lysosome-targeted fluorescent chemodosimeter, 1, was developed for monitoring endogenous and exogenous H2S by in vivo imaging of HeLa cells, D. melanogaster and C. elegans. In the tests of mutated C. elegans (SRP-6 nulls), chemodosimeter 1 could trace the accumulation of lysosome and lysosomal injury with a high resolution.

Graphical abstract: A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging

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Article information

DOI
https://doi.org/10.1039/C4CC05539J
Article type
Communication
Submitted
18 Jul 2014
Accepted
17 Sep 2014
First published
17 Sep 2014

Chem. Commun., 2014,50, 13833-13836

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A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging

X. J. Zou, Y. C. Ma, L. E. Guo, W. X. Liu, M. J. Liu, C. G. Zou, Y. Zhou and J. F. Zhang, Chem. Commun., 2014, 50, 13833 DOI: 10.1039/C4CC05539J

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