Issue 75, 2014
From the journal:

Chemical Communications

Cyclometalated Ir(iii) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy†

Rui-Rong Ye,a   Cai-Ping Tan,*a   Liang He,a   Mu-He Chen,a   Liang-Nian Jia  and  Zong-Wan Mao*a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China
E-mail: cesmzw@mail.sysu.edu.cn, tancaip@mail.sysu.edu.cn
Fax: +86-20-8411-2245

Abstract

The successful design and anticancer mechanistic studies of a series of cyclometalated Ir(III) complexes with histone deacetylase inhibitory and photodynamic therapy (PDT) activities are reported.

Graphical abstract: Cyclometalated Ir(iii) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C4CC05215C
Article type
Communication
Submitted
07 Jul 2014
Accepted
29 Jul 2014
First published
30 Jul 2014

Chem. Commun., 2014,50, 10945-10948

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Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy

R. Ye, C. Tan, L. He, M. Chen, L. Ji and Z. Mao, Chem. Commun., 2014, 50, 10945 DOI: 10.1039/C4CC05215C

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