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Issue 91, 2014
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Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

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Abstract

The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.

Graphical abstract: Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

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Article information


Submitted
04 Jul 2014
Accepted
18 Sep 2014
First published
19 Sep 2014

Chem. Commun., 2014,50, 14201-14204
Article type
Communication

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

A. Benjdia, K. Heil, A. Winkler, T. Carell and I. Schlichting, Chem. Commun., 2014, 50, 14201
DOI: 10.1039/C4CC05158K

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