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Issue 95, 2014
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Synthesis aided structural determination of amyloid-β(1–15) glycopeptides, new biomarkers for Alzheimer's disease

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Abstract

Unique tyrosine glycosylated amyloid-β(1–15) glycopeptides were synthesized with well-defined stereochemistry at the glycosidic linkages. Aided by these glycopeptides and tandem mass spectrometry analysis, the naturally existing amyloid-β glycopeptides, isolated from Alzheimer's disease patients, were determined to contain an α-linked N-acetyl galactosamine at the modified tyrosine 10 residue. Glycosylation can significantly impact the properties of amyloid-β as the glycopeptide has much lower affinity for Cu+ ions.

Graphical abstract: Synthesis aided structural determination of amyloid-β(1–15) glycopeptides, new biomarkers for Alzheimer's disease

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Supplementary files

Article information


Submitted
03 Jul 2014
Accepted
08 Oct 2014
First published
09 Oct 2014

Chem. Commun., 2014,50, 15067-15070
Article type
Communication
Author version available

Synthesis aided structural determination of amyloid-β(1–15) glycopeptides, new biomarkers for Alzheimer's disease

P. Wang, J. Nilsson, G. Brinkmalm, G. Larson and X. Huang, Chem. Commun., 2014, 50, 15067
DOI: 10.1039/C4CC05085A

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