COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

Abstract

A labelling method for the covalent attachment of radioiodine to the boron-rich 8-I-cobaltabisdicarbollide (I-COSAN) and a bi-functional (iodine and PEG) COSAN derivative, [3,3′-Co(8-I-1,2-C₂B₉H₁₀)(8′-(OCH₂CH₂)₂COOC₆H₅-1′,2′-C₂B₉H₁₀)], is reported. Biodistribution studies in rodents using dissection/gamma counting and in vivo nuclear imaging have been performed. The general strategy reported here can be applied in the future to COSAN derivatives bearing a wide range of functionalities.