Issue 81, 2014
From the journal:

Chemical Communications

Acid-catalyzed acylation reaction via C–C bond cleavage: a facile and mechanistically defined approach to synthesize 3-acylindoles†

Qi Xing,ab   Pan Li,a   Hui Lv,a   Rui Lang,a   Chungu Xiaa  and  Fuwei Li*a  

* Corresponding authors

a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
E-mail: fuweili@licp.cas.cn

b University of Chinese Academy of Sciences, Beijing, China

Abstract

A facile acid-catalyzed acylation of indoles with 1,3-dione as an eco-friendly acylating agent was developed. This protocol combines C–C bond cleavage and heterocyclic C–H bond functionalization to form new C–C bonds. Based on the detailed mechanistic studies, a credible mechanistic pathway was proposed.

Graphical abstract: Acid-catalyzed acylation reaction via C–C bond cleavage: a facile and mechanistically defined approach to synthesize 3-acylindoles

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Article information

DOI
https://doi.org/10.1039/C4CC05047A
Article type
Communication
Submitted
02 Jul 2014
Accepted
21 Aug 2014
First published
21 Aug 2014

Chem. Commun., 2014,50, 12181-12184

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Acid-catalyzed acylation reaction via C–C bond cleavage: a facile and mechanistically defined approach to synthesize 3-acylindoles

Q. Xing, P. Li, H. Lv, R. Lang, C. Xia and F. Li, Chem. Commun., 2014, 50, 12181 DOI: 10.1039/C4CC05047A

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