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Issue 80, 2014
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Silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides: divergent synthesis of indolizines and pyrroles

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Abstract

Divergent syntheses of indolizines and 2,4-disubstituted pyrroles by the silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides are reported. These methods provide an effective route to highly functionalized indolizines and 2,4-disubstituted pyrroles in good to excellent yields. The 2,4-disubstituted pyrroles are synthesized by an unprecedented regioselective [3+2] cycloaddition of terminal alkynes with isocyanides.

Graphical abstract: Silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides: divergent synthesis of indolizines and pyrroles

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Supplementary files

Article information


Submitted
27 Jun 2014
Accepted
12 Aug 2014
First published
22 Aug 2014

Chem. Commun., 2014,50, 11837-11839
Article type
Communication
Author version available

Silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides: divergent synthesis of indolizines and pyrroles

X. Meng, P. Liao, J. Liu and X. Bi, Chem. Commun., 2014, 50, 11837
DOI: 10.1039/C4CC04905E

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