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Issue 67, 2014
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Pyrazine-derived disulfide-reducing agent for chemical biology

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Abstract

For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivity under biological conditions that is markedly superior to DTT and other known reagents.

Graphical abstract: Pyrazine-derived disulfide-reducing agent for chemical biology

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Supplementary files

Article information


Submitted
13 Jun 2014
Accepted
20 Jun 2014
First published
11 Jul 2014

Chem. Commun., 2014,50, 9591-9594
Article type
Communication

Pyrazine-derived disulfide-reducing agent for chemical biology

J. C. Lukesh, III, K. K. Wallin and R. T. Raines, Chem. Commun., 2014, 50, 9591
DOI: 10.1039/C4CC04491F

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