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Issue 87, 2014
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Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan

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Abstract

Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The chitosan nanovalves tightly close the pores of the MSNPs to control premature cargo release under physiological conditions but respond to lysozyme and acidic media to release the trapped cargo.

Graphical abstract: Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan

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Article information


Submitted
09 Jun 2014
Accepted
11 Aug 2014
First published
11 Aug 2014

Chem. Commun., 2014,50, 13268-13271
Article type
Communication

Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan

A. Hakeem, R. Duan, F. Zahid, C. Dong, B. Wang, F. Hong, X. Ou, Y. Jia, X. Lou and F. Xia, Chem. Commun., 2014, 50, 13268
DOI: 10.1039/C4CC04383A

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