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Issue 73, 2014
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A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine

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Abstract

The self-assembly of a lipophilic derivative of (5′S)-5′,8-cyclo-2′-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.

Graphical abstract: A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine

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Publication details

The article was received on 04 Jun 2014, accepted on 24 Jul 2014 and first published on 24 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04275A
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Citation: Chem. Commun., 2014,50, 10722-10725
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    A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine

    S. Pieraccini, M. A. Terzidis, E. J. Baldassarri, G. Fragneto, P. Mariani, S. Masiero and C. Chatgilialoglu, Chem. Commun., 2014, 50, 10722
    DOI: 10.1039/C4CC04275A

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