Melireth Holmquist, Gonzalo Blay and José R. Pedro
Chem. Commun., 2014,50, 9309-9312
DOI:
10.1039/C4CC04051A,
Communication
A highly enantioselective aza-Henry reaction with isatin N-Boc ketimines using a Cu(II)–BOX complex as a catalyst is described. The reaction, which does not require protection of the N1 atom, provides the corresponding nitroamines bearing a quaternary stereocentre with high yields and enantiomeric excesses (up to 99.9%).
