Issue 64, 2014
From the journal:

Chemical Communications

Enantioselective hydrogenation of α,β-disubstituted nitroalkenes†‡

Shengkun Li,*ab   Kexuan Huangb  and  Xumu Zhang*b  

* Corresponding authors

a College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, P.R. China
E-mail: saintkun001@njau.edu.cn
Tel: +86-025-84399753

b Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Chemistry, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, USA
E-mail: xumu@rci.rutgers.edu

Abstract

The first highly chemo- and enantioselective hydrogenation of α,β-disubstituted nitroalkenes was accomplished with rhodium/JosiPhos-J2 as a catalyst, with the yield and enantioselectivity of up to 95% and 94%, respectively. The α-chiral nitroalkanes will provide an entry to valuable chiral amphetamines which are otherwise not so easily accessed.

Graphical abstract: Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

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Article information

DOI
https://doi.org/10.1039/C4CC03942D
Article type
Communication
Submitted
23 May 2014
Accepted
16 Jun 2014
First published
16 Jun 2014

Chem. Commun., 2014,50, 8878-8881

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Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

S. Li, K. Huang and X. Zhang, Chem. Commun., 2014, 50, 8878 DOI: 10.1039/C4CC03942D

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